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A new study shows that the innate immune system of humans is capable of killing a fungus joined to flight path inflammation, chronic rhinosinusitis and bronchial bronchial asthma. Researchers at Mayo Clinic and the Virginia Bioinformatics Institute (VBI) have revealed that eosinophils, a picky type of white blood cell, exert a strong immune response against the environmental fungus Alternaria alternata. The groundbreaking findings, which shed light on some of the early events involved in the recognition of A. alternata by the human immune system, were published recently in the Journal of Immunology.*
Eosinophils typically armed combat parasitic invaders of the human dead body larger than bacteria or viruses, such as flukes or epenthetic worms (conjointly known as helminths). Evidence from different experimental approaches suggests that asthma and chronic sinusitis can arise when the body perceives that it has encountered a disease-causing organism. Environmental fungi such as Alternaria do not typically reason invasive infections like parasites but for some intellect, in certain people, the body responds as if it is being attacked and continuing inflammation can result from the ensuing cascade of immune-related events.
Principal Investigator Hirohito Kita, M.D., from Mayo Clinic, remarked: "Our results strongly show that eosinophils have the capacity to recognize and exert immunologic responses to certain fungi such as Alternaria. We have shown that CD11b receptors on the open of eosinophils recognize and adhere to beta-glucan, a major cell wall element of the fungus. This in turn sets in motion the release of toxic granule proteins by the white blood cells, leading to extensive price and ultimate destruction of the fungus. To the best of our noesis, this is the first time that live eosinophils and non just the intracellular components have been shown to target and destroy a fungus."
The researchers used fluorescence microscopy to determine the outcome of the interaction between eosinophils and A. alternata. The contact of fungus with eosinophils resulted in hopeful red fluorescence due to the damaged fungal cell wall and subsequent death of Alternaria. Immunohistochemistry confirmed the vent of toxic granular proteins by eosinophils due to contact with the fungus.
Dr. Chris Lawrence, Associate Professor at VBI and the Department of Biological Sciences at Virginia Tech, remarked: "T benefactor 2 (Th2) cells in the immune system typically produce cytokine signaling molecules or interleukins that tip to the recruitment of eosinophils for the dysregulated immune response commonly associated with air duct inflammatory disorders. Continual exposure of allergic individuals to common environmental fungi wish Alternaria may result in Th2 cells being forever activated to recruit eosinophils and this sustained defense team mechanism results in chronic inflammation. It has been shown previously that degranulation of eosinophils causes price of air duct mucosa and enhances firing. The next step in our transdisciplinary research collaboration will be to use recombinant fungous proteins and fungal kO mutants for specific genes to dissect the different molecular steps involved in the development and advancement of this acute immune response."
Hirohito Kita added: "We have taken an important step in showing that the congenital immune system of eosinophils is able of targeting an asthma-associated fungus for destruction. The biological significance of these results testament need to be verified further in animal models and in humans and our collaborative efforts with Dr. Lawrence's research grouping for proteomics and functional genomics will be priceless in this respect. We suspect that the dysregulated immune responses to Alternaria, other filamentlike fungi, and perhaps chitin-encased insects, such as mites and cockroaches, may toy a pivotal role in chronic lighting and the subsequent development of bronchial airway disease."
Notes:
* Juhan Yoon, Jens U. Ponikau, Christopher B. Lawrence, Hirohito Kita (2008)
Innate Antifungal Immunity of Human Eosinophils Mediated by a ?2 Integrin, CD11b. J. Immunol. 181: 2907-2915.
About VBI
The Virginia Bioinformatics Institute (VBI) at Virginia Tech (www.vbi.vt.edu) has a research platform centered on understanding the "disease triangle" of host-pathogen-environment interactions in plants, humans and other animals. By successfully channeling innovation into transdisciplinary approaches that combine information technology and biology, researchers at VBI are addressing some of today's key challenges in the biomedical, environmental and found sciences.
About Mayo Clinic
Mayo Clinic is the first and largest integrated, not-for-profit group practice in the world. Doctors from every medical specialty work together to care for patients, coupled by common systems and a ism of "the needs of the patient come first base." More than 3,three hundred physicians, scientists and researchers and 46,000 allied health staff work at Mayo Clinic, which has campuses in Rochester, Minn., Jacksonville, Fla., and Scottsdale/Phoenix, Ariz. Collectively, the deuce-ace locations treat more than half a million citizenry each year.
Source:
Barry Whyte
Virginia Tech
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Monday 8 September 2008
Friday 29 August 2008
Pick of the week: Clubs
Eastern Electrics
The Arches, London
Saturday 23 & Sunday 24
The two-day trendfest features the likes of Hercules & Love Affair, Aussie electro wonks Cut Copy, Steve Mason's Black Affair and Micach.
Bank Holiday Special
2020, Bournemouth
Sunday 24
Roger Sanchez dusts off his shorts and heads down to the south coast for a slot at 2020. Expect his usual funfair of house music.
Bass Epidemic Bank Holiday Special
Blue Mountain Club, Bristol
Sunday 24
Holby's otologists better be on standby as the bass epidemic is spread by Chase & Status, Stanza and Eddie K.
Tayo's Tracksuit Party
Paradise By Way Of Kensal Green, London,
Sunday 24
Get your "Rodney, you plonker!" heckle ready to cry at Roots Manuva,
who plays live. Joe Ransom and Ben Westbeech are on the decks.
Adventures In Success
East Village, London
Friday 29
Shoom! regulars Rock and Diesel toast 20 years of unrestrained house euphony with an East End knees up. Katie Barber and Gavin Fraser facilitate them lead the celebrations.
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Tuesday 19 August 2008
Eva Longoria Parker: "I'm a 1950s Housewife."
Forget the scheming, shocking character she plays on Desperate Housewives � Eva Longoria Parker works knockout at everything she does, whether it's giving back to the Latino community or pickings care of her basketball game star married man, Tony Parker.
Eva reveals her homebody instincts in the September issue of Latina magazine, on sale Aug. 19.
"I'm a 1950's lady of the house," she says. "I passion baking. I love stitchery. Being home with Tony."
While she struggles with rumors swirling around her marriage, Eva maintains a positively charged attitude in the face of media speculation.
"You can't fight everything that comes up," she says. "Tony and I are very blessed that we have a hard foundation and can weather anything that comes our way."
Along with filming Desperate Housewives 10 months out of the year, Eva finds time to stay involved with the Latino community as much as she tin can: For the third yr in a row, she's hosting and executive-producing the National Council for La Raza's ALMA Awards, which celebrate excellence in Latino entertainment, on Sept. 12 on ABC.
"She's obviously identical talented and beautiful," close friend and fellow actor Mario Lopez says, "only her characters aren't whacking you over the head with a tortilla."
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Saturday 9 August 2008
Sammie
Artist: Sammie
Genre(s):
R&B: Soul
Discography:
Sammie
Year: 2006
Tracks: 17
Miami's preteenager R&B vocalizer Sammie was uncovered to music horizontal surface earlier he was innate. His mother, a quondam professional isaac M. Singer, panax quinquefolius in the church inspection and repair choir plot of ground she was carrying him. Fittingly, Sammie's first recounting triumph as well occurred at church service; at eld quaternary, he received a standing standing ovation for his performance of "Troubles Don't Last Always." Music was ne'er far from Sammie's thinker, regular at school; teachers would catch him tattle under his breath during classes, but bucked up his gift. Eventually, a medicine instructor from Charles Drew Elementary, a nearby attraction shoal with a special performing liberal arts plan, heard of Sammie's vocal gifts and he transferred in that localization at the start of third appurtenance ground level. Soon after, he formed a vocal radical, the Wonder 3, with two junior high boys. Sammie's medicine teacher was so impressed with their performances that she sent a videotape of them to the boob tube plan Starting prison term at the Apollo, which lED to an tryout for the mathematical mathematical group and a 1998 solo performance for Sammie. Ultimately fetching the show's finals, Sammie and his mother were contacted by Joyce Irby, an agent connected to Atlanta-based producer/songwriter Dallas Austin, wHO has worked with Monica and Another Bad Creation. Austin brought Sammie to his studios for some demos and almost a year by and by, had him return to record his debut record album, From the Bottom to the Top, which was released in early 2000 by Capitol Records. Six onetime age later on, Austin sign him to his reactivated Rowdy label and released his self-titled album.
Tiny Masters of Today
Tuesday 1 July 2008
Santerna Pres. Fadelon
Artist: Santerna Pres. Fadelon
Genre(s):
Trance
Discography:
Altitude Feeling The Night CDS
Year: 2007
Tracks: 2
Act Of God
Monday 30 June 2008
Sunday 29 June 2008
Barry Brown
Artist: Barry Brown
Genre(s):
Reggae
Discography:
Rich Man Poor Man 1978-1980
Year: 2004
Tracks: 14
Mores Vibes Of Barry Brown
Year: 1983
Tracks: 8
Vibes Of Barry Brown
Year: 1981
Tracks: 10
Far East
Year: 1981
Tracks: 13
King Jammy Presents (Black Arrow 1980)
Year: 1980
Tracks: 9
Cool Pon Your Corner
Year: 1979
Tracks: 10
Showcase - Midnight Rock At Channel One (1979-81)
Year:
Tracks: 6
Roots And Culture (Studio One LP 2002)
Year:
Tracks: 14
Reggae Nights
Year:
Tracks: 18
Barry Brown meets Cornel Campbell
Year:
Tracks: 18
Jacob the Jeweler to Bling it Behind Bars
The Clark Sisters
Artist: The Clark Sisters
Genre(s):
Classical
Discography:
Live One Last Time
Year: 2007
Tracks: 17
Dj_Quest
U.S. Bombs
Artist: U.S. Bombs
Genre(s):
Rock: Punk-Rock
Discography:
We Are The Problem
Year: 2006
Tracks: 15
Covert Action
Year: 2003
Tracks: 13
The World
Year: 1999
Tracks: 18
Nevermind the Opened Minds
Year:
Tracks: 6
Aretha Franklin Headlines Newport Jazz Festival
Aretha Franklin [ tickets ] has been tapped to headline the 2008 JVC Jazz Festival [ tickets ] Aug. 9 in Newport, RI. The Queen of Soul will be joined at this year's Newport fest by Sonny Rollins [ tickets ], Wayne Shorter [ tickets ], Chris Botti [ tickets ] and Herbie Hancock [ tickets ], among others.The festival will kick off Aug. 8 with Botti and Ledisi [ tickets ] at the International Tennis Hall of Fame at the Newport Casino. The following two days of the fest will be held at Fort Adams State Park.
Head Automatica
Artist: Head Automatica
Genre(s):
ROck: Alternative
Rock
Discography:
Popaganda
Year: 2006
Tracks: 13
Beating Heart Baby
Year: 2005
Tracks: 3
Tokyo Decadence
Year: 2004
Tracks: 14
Decadence
Year: 2004
Tracks: 11
Head Automatica was the slightly unlikely mating of vocalist Daryl Palumbo -- he of N.Y.C. hard-core stalwarts Glassjaw -- and producer Dan the Automator (aka Dan Nakamura of Gorillaz, Handsome Boy Modeling School). Introduced by common friends, the duette began turn on their debut, aiming for a good somewhere in between the Automator's beat generation and squiggles and Palumbo's preference for john Rock and punk. When Degeneracy appeared in recent summertime 2004, its groove was just that, a bright and rubbishy shuffle of electronics and rock & drift, the tolerant of thing for which late nights were made. Palumbo and Automator place together a route band and toured the disc, hooking up with such disparate acts of the Apostles as Lostprophets, Thrice, Interpol, and the Rapture. However, Palumbo's ongoing fight with Chron's disease, which the vocalizer suffered from since childhood, continued to turn over him problems spell on the road; assorted tour of duty dates had to be canceled as he exhausted time in and out of hospitals getting handling. He continued to recidivate as work on Head Automatica's sophomore Warner Bros. campaign began (and persisted during most all of its recordings). The ring -- now comprised of Palumbo, drummer Larry Gorman (ex-Glassjaw), bassist Jarvis Morgan Holden (ex-Give Up the Ghost), guitarist Craig Bonich, and keyboardist Jessie Nelson -- aquiline up with manufacturer Howard Benson to help create an record album with a "bright, frosty good." The resulting Popaganda was issued in June 2006. It proved to be an ably named record album that, without Dan the Automator round, largely lacked the electronics of Decadency, instead self-praise a relatively more straightforward guitar heavy for the most part influenced by tardy '70s pop. A subsequent summer tour of duty was fagged opening for Taking Back Sunday aboard Angels and Airwaves and the Subways.
Fire Town
Change Made in Britney Visitation Status
Things are finally looking up for Britney Spears! It was just announced that there has been a change in her visitation status with her two young sons. While it has yet to be made public what exactly that change is, insiders tell OK! that the pop star went into court today to ask for once-weekly overnight visits with the boys, and it's believed she may have gotten her wish granted.
When she left the court after meeting with commissioner Scott Gordon and lawyers for her and ex-husband Kevin Federline, Brit's eyes appeared to be bloodshot, as if she'd been crying. However, when asked if she was happy, she replied, "yes," so hopefully those were tears of joy.
A rep for the court confirmed that, while it was not strictly considered as testimony, Gordon did ask Britney a number of questions during their closed-door hearing. Also speaking to the court today was Lisa Hacker, the court-appointed parenting coach for the pop star.
As for her demeanor in the courtroom today, the court spokesperson described Britney as being "very businesslike," and confirmed that there were no words of any kind exchanged between Brit and K-Fed.
It was also confirmed after the hearing that Brit's most-recent attorney, Stacy Phillips, "has exited the case," and that her one-time lawyer, Laura Wasser, has returned to represent the singer.
The next hearing date is scheduled for July 15, and the court confirms that a trial date is still tentatively set for August, though the spokesperson did say that this will continue, "for as long as it takes to resolve this case."
See Also
Saturday 28 June 2008
Amy Winehouse - Fielder-civils Assault Victim Cleared In Bribery Plot
The London pub landlord accused of teaming up with AMY WINEHOUSE's husband BLAKE FIELDER-CIVIL to pervert the course of justice has been cleared of the charge.
Fielder-Civil is accused of causing grievous bodily harm to pub owner James King in an incident in June 2006. In a bizarre twist, the 26-year-old was then charged with teaming up with King to try to fix the outcome of that trial, by offering him a $400,000 (GBP200,000) bribe.
Fielder-Civil - who is on remand at the capital's Pentonville Prison - initially denied the charges, but entered a guilty plea to both counts at the start of his trial at Snaresbrook Crown Court in east London earlier this month (Jun08).
King, 36, faced one count of perverting the course of justice - but was acquitted of taking the cash bribe when the jury delivered their first verdict on Wednesday (25Jun08).
Fielder-Civil's co-defendant Michael Brown, 25 has pleaded guilty to a charge of grievous bodily harm, while Brown, Anthony Kelly, 25, and James Kennedy, 19, have all pleaded guilty to perverting the course of justice.
Winehouse's spouse, who faces up to five years behind bars for the allegations, and his remaining co-defendants are awaiting the jury's verdict and will be sentenced in due course.
See Also
Fito Paez
Artist: Fito Paez
Genre(s):
Rock
Latin
Discography:
Mi Vida Con Ellas, Vol. 2
Year: 2005
Tracks: 9
Mi Vida Con Ellas, Vol. 1
Year: 2005
Tracks: 9
Naturaleza Sangre
Year: 2003
Tracks: 14
Antologia (cd2)
Year: 2002
Tracks: 15
Antologia (cd1)
Year: 2002
Tracks: 15
Rey Sol
Year: 2000
Tracks: 13
Abre Paez
Year: 1999
Tracks: 12
Euforia
Year: 1996
Tracks: 16
Circo Beat (Beat Circus)
Year: 1994
Tracks: 13
El Amor Despues del Amor
Year: 1992
Tracks: 14
Cronica
Year: 1991
Tracks: 14
Tercer Mundo
Year: 1990
Tracks: 10
Ey!
Year: 1988
Tracks: 9
Ciudad de Pobres Corazones
Year: 1987
Tracks: 11
La La La
Year: 1986
Tracks: 19
Corazon clandestino
Year: 1986
Tracks: 4
Giros
Year: 1985
Tracks: 9
Del '63
Year: 1984
Tracks: 9
Misc
Year:
Tracks: 8
Canciones para mi hada madrina
Year:
Tracks: 16
Rodolfo "Fito" Paez was natural in Rosario, Argentina on March 13, 1963. He formed Staff, his low gear stria when he was 13. In 1977, he played in El Banquette with Rubén GoldÃn and Jorge Llonch. He began to appear solo in pubs the following year. Straight out of high school, he began touring with several bands and presently subsequently that produced his first gear solo record album, Del '63, which was released in 1984. It was promoted low gear in his home townspeople, merely by and by earned attention in Buenos Aires. The recording was put in concert with the help of some of Argentina's virtually prominent musicians, including Daniel Wirtz, Fabián Gallardo, Tweety González and Paul Dorge. The disk south Korean won him critical applaud as a songwriter and helped lead to future projects, including a 1985 record album, Giros. The demo of that album earned him the praise of Luis Alberto Spinetta, as well as a partnership -- Paez's next album, 1986's La La La was a couple with Spinetta. The couple supported that album with a duty tour that reached all the way to Santiago de Chile. The same class, he participated in the Thousand Days of Democracy festival with Spinetta, Juan Carlos Baglietto, Silvina Garré and Antonio Tarragó Ros. His 1987 recording, Ciudad de Pobres Corazones, pronounced a dark, political turn for his influence. It was dedicated to the memory of his aunt and nanna, world Health Organization were assassinated in Rosario. The record album seethed with wrath, simply it was likewise more rhythmic and showed greater songwriting depth than his previous recordings.
Paez got his first taste of production make for with Ey, which was released in 1988. Recorded in New York and Havana, it too showcased many of the musicians that he had worked with previously, including Guillermo Vadalá, Guillermo Colombres and Osvaldo Fattoruso. It too featured the trumpeters and saxophonists of the group, Afrocuba. Less rough than his previous recording, it was one of his near balanced records. Tercer Mundo, released in 1990, explores Latin American cultural influences and showed the harsh universe of poorness and exploitation. It, too was critically acclaimed, simply it was Paez' 1992 record album, El Amor Después del Amor that pronounced the pinnacle of his commercial success. The record album sold more than 600,000 copies and when Paez toured to financial support it, he establish himself playacting to sold-out shows for 40,0000 citizenry. Shortly later its release, he played a benefit concert for UNICEF which raised more than $420,000. The followup, Circo Beat, had impossibly high school expectations and though it had several strike songs, including "Mariposa lily Tecknicolor" and "Tema de Piluso," as well as a companion album, Circo Beat Brazil, which featured Brazilian remixes of its hits, it only sold about 350,000 copies. Several other projects were completed in the late '90s, including an acoustic album, Euforia and 1998's Sabrina & Paez: Enemios Intimos. The twelvemonth 2000 brought another balanced, wondrously produced album, Abre Paez. He too took home iI Grammys at the number one annual Latin Grammy Awards in come down 2000.
Sean Bean marries for fourth time
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